Botox, Xeomin, and Jeuveau: A Comprehensive Comparison by Setiba Med Spa


Neuromodulators have become a cornerstone for achieving youthful, wrinkle-free skin. At Setiba Med Spa in Westlake Village, CA, we offer three of the most popular options: Botox, Xeomin, and Jeuveau. Each of these treatments can help reduce the appearance of fine lines and wrinkles, but they have unique characteristics that may make one a better choice for your specific needs. In this comprehensive guide, we’ll explore the differences between Botox, Xeomin, and Jeuveau to help you make an informed decision.

Introduction to Neuromodulators

Neuromodulators are injectable treatments that temporarily relax the muscles responsible for creating dynamic wrinkles, such as crow’s feet, frown lines, and forehead creases. By inhibiting the signals from nerves to muscles, these products smooth out existing wrinkles and prevent new ones from forming.

What Are Botox, Xeomin, and Jeuveau?

Botox: Botox, developed by Allergan, is the most well-known and widely used neuromodulator. Approved by the FDA in 2002 for cosmetic use, Botox has a long track record of safety and effectiveness.

Xeomin: Xeomin, produced by Merz Pharmaceuticals, received FDA approval in 2010. It is known for being a “naked” injectable, meaning it contains only the active botulinum toxin without any accessory proteins.

Jeuveau: Jeuveau, manufactured by Evolus, is the newest of the three, gaining FDA approval in 2019. Often referred to as “Newtox,” Jeuveau was developed specifically for aesthetic purposes and has quickly gained popularity.

How They Work

All three products use botulinum toxin type A as their active ingredient, which temporarily paralyzes muscles to reduce wrinkles. However, there are slight differences in their formulations:

  • Botox contains accessory proteins that protect the botulinum toxin molecule.
  • Xeomin is free of these accessory proteins, potentially reducing the risk of an immune response.
  • Jeuveau uses a similar molecular structure to Botox but is produced with a different manufacturing process.

Treatment Areas

Botox, Xeomin, and Jeuveau are all effective for treating common areas such as:

  • Forehead lines
  • Glabellar lines (frown lines between the eyebrows)
  • Crow’s feet (lines around the eyes)

Unique Advantages:

  • Botox is also used for medical conditions like migraines, excessive sweating, and muscle spasms.
  • Xeomin’s pure formulation may be preferable for patients who have developed resistance to Botox.
  • Jeuveau is marketed specifically for aesthetic purposes, often appealing to younger patients seeking preventative treatments.

Efficacy and Results

Onset and Duration:

  • Botox: Results typically appear within 3-5 days and can last 3-4 months.
  • Xeomin: Results may take slightly longer to appear, around 5-7 days, but the duration of effect is similar to Botox, lasting about 3-4 months.
  • Jeuveau: Results are usually noticeable within 2-4 days and can last 3-4 months.

Effectiveness: Clinical studies and patient reviews suggest that all three neuromodulators are highly effective at reducing wrinkles. However, individual responses can vary, and some patients may prefer one product over another based on their personal experience.

Side Effects and Safety

Common side effects for all three treatments include:

  • Redness and swelling at the injection site
  • Bruising
  • Headache
  • Temporary drooping of eyelids or eyebrows (rare)

Unique Considerations:

  • Botox: The presence of accessory proteins may increase the risk of developing antibodies that reduce its effectiveness over time.
  • Xeomin: The absence of accessory proteins may lower the risk of an immune response, making it a suitable option for those who have become resistant to Botox.
  • Jeuveau: Its specific aesthetic formulation is designed to provide a high level of purity and effectiveness for cosmetic use.

Cost Comparison

The cost of neuromodulator treatments can vary based on factors such as the number of units required, the area being treated, and the experience of the injector. On average:

  • Botox: Typically costs around $10-15 per unit.
  • Xeomin: Generally priced similarly to Botox, around $10-15 per unit.
  • Jeuveau: Often positioned as a cost-effective alternative, with prices ranging from $8-14 per unit.

At Setiba Med Spa, we offer competitive pricing and personalized consultations to determine the most cost-effective treatment plan for your needs.

Ideal Candidates


  • Suitable for most adults looking to reduce the appearance of dynamic wrinkles.
  • Also beneficial for individuals seeking treatment for medical conditions such as migraines or hyperhidrosis.


  • Ideal for patients who have developed resistance to Botox.
  • Great for those who prefer a product with fewer additives.


  • Popular among younger patients seeking preventative treatments.
  • Attractive to those looking for a neuromodulator specifically designed for cosmetic purposes.

Patient Experience

During Treatment:

  • All three treatments involve a series of small injections.
  • The procedure typically takes 10-20 minutes.
  • Most patients experience minimal discomfort, often described as a slight pinch.

After Treatment:

  • There is no downtime, and you can resume normal activities immediately.
  • Avoid strenuous exercise, alcohol, and excessive sun exposure for at least 24 hours.
  • Full results are typically visible within a week.

Practitioner Considerations

Choosing a qualified and experienced practitioner is crucial for achieving the best results with Botox, Xeomin, or Jeuveau. At Setiba Med Spa, our team of skilled professionals is dedicated to providing safe and effective treatments tailored to your individual needs.

Comparative Summary

Feature Botox Xeomin Jeuveau
FDA Approval 2002 2010 2019
Formulation Contains accessory proteins “Naked” formulation Pure toxin for aesthetics
Onset of Results 3-5 days 5-7 days 2-4 days
Duration of Results 3-4 months 3-4 months 3-4 months
Common Treatment Areas Forehead, frown lines, crow’s feet Forehead, frown lines, crow’s feet Forehead, frown lines, crow’s feet
Cost per Unit $10-15 $10-15 $8-14


Choosing between Botox, Xeomin, and Jeuveau can be challenging, but understanding their differences and benefits can help you make an informed decision. At Setiba Med Spa in Westlake Village, CA, we are committed to helping you achieve your aesthetic goals with personalized care and expertise. Whether you choose Botox, Xeomin, or Jeuveau, our experienced practitioners will guide you through the process to ensure you achieve the best possible results.

If you’re ready to reduce the appearance of wrinkles and enjoy smoother, younger-looking skin, contact Setiba Med Spa today to schedule your consultation. Let us help you discover the perfect neuromodulator treatment for your unique needs.

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